Original research
par
Bedard, Madigan et al
Date de publication
2024
Géographie
USA
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Oui
Évalué par des pairs
Yes
L’objectif
This study examines the impact of xylazine alone and in combination with fentanyl on several behaviors in mice.
Constatations/points à retenir
Surprisingly, naloxone precipitates withdrawal from xylazine and fentanyl/xylazine coadministration, with enhanced sensitivity in female mice. Further, xylazine is a full agonist at kappa opioid receptors, a potential mechanism for its naloxone sensitivity. Finally, we demonstrate surprising effects of xylazine to kappa opioid antagonism, which are relevant for public health considerations.
Mots clés
Illegal drugs
Mortality
Outcomes
Overdose
Withdrawal
